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Son - ADHD, Slow Processing Speed, Comprehension - Many gene mutations, help!
TLN Offline
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Son - ADHD, Slow Processing Speed, Comprehension - Many gene mutations, help!
Hi Everyone!

My Son is 9 years old. Super sweet, no behaviour problems. But suffers from mood issues, memory problems, slow processing speed and has trouble with comprehension, ADHD symptoms (Combined ADHD - has both inattentive and hyperactive-impulsive symptoms). He has a difficult time explaining anything. It takes him two or three times as long to explain a story or event. He gets confused with simple tasks. I sometimes feel like his brain is simply confused or scattered.

His moods consist of either:
1. Happy and easy to deal with. Snaps out of a bad mood quickly .. within minutes.
2. Grouchy, difficult, going against the grain almost like he is trying to make everything unenjoyable. Nothing and I mean nothing snaps him out of it.

For example: June and July he was grouchy. August and part of Sept he has been amazing mood wise. This is Sept. 20th and about 3 days ago something changed.. the great wonderful mood he has been in for weeks has changed to extremely hyper almost like he's vibrating. He can't sit still or stop talking (much worse then normal). He seems to be forgetting things constantly and confused. He's not overly grouchy but not overly happy either.
This hyper,vibrating mood cycles every few months. His moods cycle between either happy, grouchy or vibrating. Nothing you try and do can get him to calm down. He's excited about the fun he's having at school with new friends etc. but it's way way way over the top excited. He does get this way when he knows something exciting is coming up like a birthday or a holiday for example.

He is in grade 4 and is suffering greatly. He has been going to a Naturopathic Doctor for a while now and there has been some improvement but is still suffering. He takes a LOT of supplements. We have just received his genetic report and I was wondering if anyone can make sense of what is happening with him. Why his brain is not functioning as it should. He has a LOT of mutations. I've read a lot of Dr. Amy's literature among other Dr.'s such as Ben Lynch but I find it difficult to understand unfortunately so I found this forum and thought I would post and see if anyone can help me to help him. I've had another Dr. take a look at his genetics and I will post [b]his response below.

He is taking the following supplements:

-Amino Acids: N-Acetyl-L-carnitine, Alpha Lipoic Acid, N-Acetyl-L-cysteine, Coenzyme Q10, N-Acetyl Tyrosine
- TMG
-5HTP
-Sam-e
- Zinc
- B6
Vitaspectrum Multi
Magnesium, Myo-Inositol, Taurine,Gaba, L-Theanine (this is a drink called relaxmax)
Phospholipids. Phosphatidyl Serine by Douglas Labs
Creatine
Methyl-B12 injections 3x week
EPA + oil (1 tsp/day)

So I am giving him lots of methyl donars but his wheel is still not turning. It's as if it gets going but it won't go any further. I am stumped. 2 other ND's seem to be stumped too as to what more they can do. I am DESPERATE for help. I don't know where to go from here. My heart is breaking for him. If anyone knows of someone that maybe deals with brain/neurological disorders like this, please let me know. I'm basically looking for someone to get his brain working as it should. It sounds crazy, but that is what I'm doing. I spend countless hours on google reading and trying to figure this out on my own but I find it so confusing. I am even more confused now to have received this genetics.

Here are some of his mutations:

METHYLATION/HOMOCYSTEINE:

Homozygous (+/+)

MTHFR C677T
COMT V158M, H62H
MAO-A
MTRR A66G, C32295T, MTRR T*662A
CBS A360A, C*351T, T*330C
FOLR2 G-1316A
MAT1A C1131T, C15656T
NOS3 A6251T, G6797A
PEMT G634A, T17020543A
SULT2A1 G9696A

Heterozygous (+/-)

MTR A50417C (MANY)
MTRR-11 A664A, C524T
VDR Bsm, VDR Taq
BHMT-02, -08
TCN2 C766G
CTH A11886G, A32114G, G25229T, T16147C, T8763C
DHFR A16352G, A20965G, C19483A
DHFR/MSH T-473A, G67591T, T835C
GAMT C9110T, G7497A
MTHFD1 R635Q, A33780G
MTHFD1L 671171A, T31397C
MTHFS-ST20 MTHFS G39646A
MUT T24234C
NOS1 A57373G, T2202C
N0S3 C19635T
SULT1C3 G535A, M194T
SULT2A1 G9696A

TRANS-SULFURATION PATHWAY

Homozygous (+/+)

CBS A360A, C*351T, T*330C
SULT2A1 G9598T

Heterozygous (+/-)

CTH A11886G, A32114G, G25229T, T16147C, T8763C
MTHFS-ST20 MTHFS G39646A
MUT T24234C

DETOX:

Homozygous (+/+)

PON1 Q129R
AGT M235T/C4072T
CYP1B1 T241A
CYP1B1 N4535
CYP2C19 T98C
CYP3A4*16 T185S
ABP1/DAO H664A
ADK G509567T
AGT M235T/C4072T

Heterozygous (+/-)

ACE G2328A
SOD3 489 C>T
CYP1A2 164A>C
CYP1B1 L432V
CYP2C9*3 A1075C
CYP2D6 S486T
GSTP1 l105V
NAT2 l114T, K268R

MITOCHONDRIAL FUNCTION:

Homozygous (+/+)

ALDH2 T12488C
MTRR A66G, C32295T, T*662A
MAT1A C1131T, C15656T
PEMT G634A, T17020543A
NOS3 A6251T, N0SG6797A
NDUFS7

Heterozygous (+/-)

ALDH2 T35023C
COX6C
DMGDH G67591T, T835C
GAMT
MTHFD1 C105T
MTHFD1L A33780G, G71171A, T311397C
MTRR-11 A664A, C52 4T, G15734A
MUT T24234C

NEUROTRANSMITTER PATHWAY (GLUTAMATE & GABA):

Homozygous (+/+)

MAOA R297R/G492T/T941G
MAOA T1011C/1460C
MAOA T89113C
ALDH2 T12488C
ANKK1 G318R
COMT H62H, T26501G, V158M
DBH (MANY)
DDC C186233T
DRD2 (MANY)
NOS3 A6251T, G6797A
PAH C35625G, C45188T
PEMT G634A, T17O23592G
PNMT G-184A
SLC6A2 A40223G, A45583C, G32299A, G47034T
SLC6A3 A3609G, T26639C

Heterozygous (+/-)

ALDH2 T35023C
ANK3 T62085337C
COMT A309G, A7406G, C28914T, G*522A, G28299A, T13376G
DDC A14870G (MANY)
DHFR A16352G (MANY)
GCH1, A14340G, G19512A
N0S1 A57373G, T2202C
PAH C81837T, G*187A, T32409C
SLC6A2 G13486A
SLC6A3 G37899A, G55467A, G56022A
THV112M
GAD1 (MANY)

COMT ACTIVITY:

Homozygous (+/+)

ALDH2 T12488C
ANKK1 G318R
COMT H62H, T26501G, V158M
CYP1B1 N453S
DBH A1410G (MANY)
DRD2 A32594G (MANY)
DRD3 G25A
MAOA R297R/G492T/T941G
MAOA T1011C/1460C
MAOA T89113C
PAH C35625G, C45188T
PNMT G-184A
MAT1A C1131T, C15656T

Heterozygous (+/-)

ALDH2 T35023C
ANK3 T62085337C
COMT A309G, A7406G, C28914T, G*522A, G28299A, T13376G
CYP1B1 L432V
DRD2 A33029G, A4651G
PAH C81837T, G*187A, T32409C
TH V112M
GAMT C9110T, G7497A
COX5A
DMGDH G67591T, T835C

Organic Acids Test:
-High oxalates
-low neurotransmitters

The latest ND has come to this conclusion but has not offered any further advice on what can be done for him. He says to stay on the same supplements but discontinue the B12 and use a cream. He also said he needs more methyl-folate and a higher dose of N-Acetyl Tyrosine.

Here is his summary on my Son based on a phone consultation:

In order to answer the question WHY your Son has mood and cognition issues we need to look at the big picture.

Our moodiness, learning and focus/concentration ability are all symptoms of brain function. Our brain is the most energy dependent and toxin sensitive organ in our body. What is causing his behaviour fluctuations are changes in the chemistry of his brain - whether he has too little or too many neurotransmitters. It is a bell curve where if our neurotransmitters are too low our memory, focus and mood changes drastically. These low neurotransmitter issues are common with oppositional behaviour, anger, grumpiness, etc. In other words, when dopamine and norepinephrine are LOW then there tends to be a shift towards anger as well as a reduced ability of the brain to function at an optimum level. Comparing this to high neurotransmitters and catecholamines (dopamine, norepi, epi) we get mood and cognition changes but from a different flavor. People with high neurotransmitters become very anxious, worrisome, and panicky. Often this can lead to types of psychosis or hallucinations if the dopamine levels go high enough. This high neurotransmitter type doesn't sound like your Son.

Looking at the testing, OAT, and genetics its my opinion that he has LOW NEUROTRANSMITTERS too often, and this is compromising his brain function (mood, attitude, learning). Low neurotransmitters goes along with a general protein deficiency in the body - this slows growth as well. So when he was born via c-section he didn't get great gut bacteria. This his challenges with sleeping/breathing/airflow due to swollen adenoids and the subsequent antibiotics and treatment didn't help his gut bacteria either. Then you combine that with his genetics like FUT2, AGT, etc. it just makes his gut have a harder time of producing amino acids for his brain. At the end of the day that is the big problem I see with Gavin. He is struggling to feed his brain what his brain requires to have a good mood, good focus and good learning ability. Without enough dopamine HE CANNOT LEARN QUICKLY. Literally his ability to learn and focus depends on how much dopamine he has in his frontal lobe. Right now all signs point to that being too low, esp. given the challenges he has faced in his gut.

His brain function is a direct reflection of his digestive systems ability to feed the brain what it needs. The gut must also be healthy to reduce inflammation that makes the brain function worse. Two things - feed the brain and reduce inflammation - that is what the gut must do.
(This post was last modified: 09-20-2016 08:37 PM by TLN.)
09-20-2016 08:30 PM
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